Kajian Praklinis Ekstrak Etanol Herba Tridax procumbens (Linn.) sebagai Antidiabetik pada Tikus Putih Diabetes (Rattus norvegicus) yang Diinduksi Streptozotosin

نویسندگان

چکیده

Penelitian ini bertujuan untuk melakukan kajian praklinis efek antidiabetes dari ekstrak etanol herba Tridax procumbens (Asteraceae) pada tikus diabetes yang diinduksi streptozotocin. Prosedur penelitian dimulai dengan mengumpulkan sampel uji Linn (TP). Seluruh bagian tanaman TP telah dikeringkan diekstraksi (95%) cara dimaserasi selama 72 jam, selanjutnya dilakukan skrining fitokimia mengetahui kandungan metabolit sekundernya secara umum. Untuk Uji menginduksi Wistar jantan streptozotocin (50 mg/kg, ip) dan nicotinamide (120 ip). Tikus diobati glibenklamid (0,25 po) (250 500 p.o.) 21 hari berturut-turut. Sampel darah dikumpulkan berkala mengukur hipoglikemik ektrak TP. Kemudian, variasi berat badan mingguan dipantau semua hewan percobaan. Hasil menunjukkan memiliki antidiabetik signifikan terhadap putih (Rattus norvegicus), hasil terbaik pemberian dosis mg/KgBB.

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ژورنال

عنوان ژورنال: Jurnal Sains dan Kesehatan

سال: 2023

ISSN: ['2303-0267', '2407-6082']

DOI: https://doi.org/10.25026/jsk.v5i1.1597